Monday, May 18, 2020

In Breast Cancer, The Estrogen-Estrogen Receptor Complex

In breast cancer, the estrogen-estrogen receptor complex cause cell proliferation (Frank, 2013). Hormone therapies can target the effects of hormones in two ways: 1) by stopping the production of estrogen and testosterone, reducing their levels, and 2) by binding to the hormone receptor and blocking the hormone from binding (Frank, 2013). In breast cancer, drugs such as Lupron â€Å"prevent the ovaries from making estrogen by blocking cues from the brain that regulate the ovaries† (Frank, 2013). In prostate cancer, Lupron works the same way to prevent the testes from producing testosterone (Frank, 2013). Drugs such as tamoxifen (breast cancer) and flutamide (prostate cancer) bind to their respective hormone receptors and bloc the hormone from†¦show more content†¦To even have a chance at success, health education programs must be implemented before the age of 14 (Williams, 1987). Health education programs are being implemented in schools that will teach about the dang ers of smoking and passive smoking (Williams, 1987). This is a preventative measure to decrease the amount of people in society who are smoking and prevent children from picking up this habit. Another health disparity is ethnic background. A study found that Asian women are â€Å"referred for late treatment for a breast lump† compared to Caucasian women (Winship, 1997). Part of this disparity is the disbelief that Asian women can/will develop breast cancer (Winship, 1997). Hospitals and medical professionals also contribute to this disparity with ignorance towards minority cultures and lack of interpreters (Winship, 1997). There must be changes implemented to medical and nursing training as well (Winship, 1997). Medical manufacturers have been delayed with responding to the needs of â€Å"ethnic minorities† such as a providing a variety of shades for prosthetics (Winship, 1997). â€Å"There is a need for strategically targeted educational material† that will edu cate Asian women and women of other ethnic backgrounds about the risks of breast cancer or even developing any form of cancer (Winship, 1997). In prostate cancer, there is a very high incidence and mortality rate seen in black Americans (Gilligan, 2005). There are major socialShow MoreRelatedTaking a Look at Breast Cancer1758 Words   |  7 PagesIntroduction Breast cancer is the most common cause of cancer-related death among females in the world. It is known for â€Å"have both a genetic and non-genetic etiology† (Milne et al., 2010). It involves a combination of several factors- such as â€Å"genetic, environmental and behavioral risk factors†- that are unique to each individual (Nickels et al., 2013). This type of cancer is represented by a malignant tumor manifested in breast cells such as the line duct and line lobules cells, just to name a fewRead MoreInvestigating Estrogen Effects On Myc And Pvt1 Expression851 Words   |  4 PagesInvestigating Estrogen Effects on MYC and PVT1 Expression in Breast Cancer Using Mouse Models Background In the United States, breast cancer is currently the second most common cancer in women. The National Institute of Health states that one in every eight women will develop breast cancer in her lifetime (1). Furthermore, it is estimated by the American Cancer Institute that approximated 41,000 people died of breast cancer in the United States during 2015 (2). Since breast cancer is such a prevalentRead MoreThe Effects of Hormones in Women Essay873 Words   |  4 Pagesspecific functions in the body. In this way, a hormone fits perfectly into a receptor perfectly, like a lock inside a key, one key, for one lock. Each of the body’s glands secretes hormones. For example, the adrenal glands secrete cortisol, epinephrine, norepinephrine, DHEA, and aldosterone. Specifically in women, the ovaries secrete the most important hormones in the body like estrogen, progesterone, and testosterone. Estrogen and progesterone are typically considered female hormones, but men also haveRead MoreWhat Is Breast Cancer?937 Words   |  4 PagesBreast cancer is one of the most common cancers and the second leading cause of cancer-related death among women in the United States. Up to 6% of breast cancers are advanced or metastatic at the time of diagnosis, requiring chemotherapy1, 2. Aberrant, accelerated growth is a hallmark of cancer3, including breast cancer. The rapid expansion of treatments targeted to aberrant cell growth – for example, cell cycle targeted chemotherapies for the treatment of metastatic breast cancer – allows for preciseRead MoreSymptoms And Treatment Of Breast Cancer Es say1032 Words   |  5 PagesBreast cancers are classified by several classifications as: - Histopathology - Grades - Stages - Receptor status. Each of these influences the prognosis and can affect treatment response. Description of a breast cancer optimally includes all of these factors: †¢ Histopathology: Breast cancer is usually classified primarily by its histological appearance. Most breast cancers are derived from the epithelium lining the ducts or lobules, and these cancers are classified as ductal or lobular carcinomaRead MorePathogenesis And Treatment Of Breast Cancer1235 Words   |  5 Pagesis known that cancer, in general, is a group of diseases that is characterized by the out-of-control growth and spread of a group of abnormal cells, which can often times result in death. More specifically, breast cancer is a hormonally dependent disease, which causes malignancy in the epithelial cells of the ducts and/or lobules of the breast (Lippman, 2012). Therefore, â€Å"women without functioning ovaries, who never receive estrogen-replacement therapy, do not develop breast cancer† (Lippman, 2012)Read MoreA Brief Note On The Mammalian Target Of Rapamycin ( Mtor )1489 Words   |  6 PagesmTOR inhibition in breast cancer. What is already known; The mammalian target of rapamycin (mTOR) is a serine/threonine kinase and downstream member of the phosphatidylinositol-3-kinase (PI3K)/protein kinase B (AKT) and adenosine monophosphate-activated protein kinase (AMPK) pathways, with an essential role in cell growth, survival, and autophagy. mTOR is a component of two structurally similar complexes, mTOR complex 1 (mTORC1) and mTOR complex 2 (mTORC2), which are however functionally distinct;Read MoreDevelopment Of The Mammary Gland9524 Words   |  39 PagesIntroduction 1. Normal mammary gland 1.1 normal mammary gland anatomies The normal breast sits on the chest muscle, consisting mainly of adipose tissue, also known as mammary fat pad. The mature mammary gland is composed of 15-20 lobes, which are each composed of smaller structure called lobules. Tiny Lactiferous ducts connect lobules to each other. (Fig. 1b) (Schneider and Bocker). A typical structure of duct is composed of a hollow lumen, enclosed by a layer of epithelial luminal cells that produceRead MoreBreast Cancer : A Complex And Heterogeneous Disease Caused By Genetic Mutations782 Words   |  4 PagesBreast cancer is a complex and heterogeneous disease caused by both genetic and non-genetic risk factors. These factors include, mutations in breast cancer-associated genes 1 and 2 (BRCA1 and BRCA2) [1]; loss or aberrant expression of the estrogen receptor (ER) [2]; human epidermal growth factor receptor (HER2) overexpression [3] ; lack of ER, progesterone receptor (PR), and epidermal growth factor receptor (EGFR) expression[4] ; high levels of re ceptor for the insulin-like growth factor receptorRead MoreLncrna Essay701 Words   |  3 Pagesassociated with diseases like cancer. They act as a precursor of siRNA and has both tumor suppression and oncogenic property. Few of the roles of lncRNA in disease are described below. (Lo, Wolfson, Zhou, 2016) MIR4435-HG It has been reported in lung cancer tissues and cell line MIRL lncRNA acts as an oncogene. This downregulation is confirmed by knocking down MIR4435-2HG in lung cancer and treating the lung cancer cells with resveratrol. In both the cases, decrease in cancer cell proliferation was observed

No comments:

Post a Comment

Note: Only a member of this blog may post a comment.